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Possible Answers:
CAST.
Last seen on: Daily Boston Globe Crossword Wednesday, 20 December 2023
Random information on the term “Play group?”:
A pre-school playgroup, or in everyday usage just a playgroup, is an organised group providing care and socialisation for children under five. The term is widely used in the United Kingdom. Playgroups are the same as preschool education and nursery schools. They can provide full-time care, or operate for only a few hours a day during school term time or all year round. The business model of a playgroup has changed across the year and they are now very similar to pre-schools, nurseries and schools. They are staffed by nursery nurses, nursery teachers or qualified nursery practitioners, and are run by private individuals or charities, rather than by the state or companies.
In the United Kingdom, since around the 1980s, the traditional territory of the playgroup has been encroached on by the expansion of more formal nursery education, and playgroups often now cater for children aged between 2 and 5 years of age before they move onto school. Over the same period there has been an increase in the state supervision of playgroups.
Random information on the term “CAST”:
The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized, controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality. It was conducted between 1986 and 1989 and included over 1700 patients in 27 centres. The study found that the tested drugs increased mortality instead of lowering it as was expected. The publication of these results in 1991/92, in combination with large follow-up studies for drugs that had not been tested in CAST, led to a paradigm shift in the treatment of MI patients. Class I and III antiarrhythmics are now only used with extreme caution after MI, or they are contraindicated completely. Heart Rhythm Society Distinguished Scientist D. George Wyse was a member of the CAST trial’s steering and executive committees.[citation needed]
The study was prompted by the fact that patients who suffer from myocardial infarctions (MIs) have a high risk of sudden death, presumably due to arrhythmia. Around the time of the study onset (1986), an estimated 8 to 15% of patients would die in the subsequent year following an MI, with about half of those deaths resulting from arrhythmia. This warranted the investigation as to whether PVC suppression could improve outcomes in post-MI patients. The trial was conducted by the National Heart, Lung, and Blood Institute.[citation needed]