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With 35-Across, he directed and starred in the original “History of the World, Part I” in 1981

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Possible Answers:

MEL.

Last seen on: Daily Beast Crossword Wednesday, March 8, 2023

Random information on the term “MEL”:

The mouse-derived erythroleukemia cell line F4N (MEL) is an aneuploid cell line, comes from mouse inbred strain DBA/2. It was established in 1977. Eight percent of the total number of cells in culture undergo spontaneous apoptosis.

MEL on Wikipedia

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