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Wine cocktail

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Possible Answers:
KIR.

Last seen on: NY Times Crossword 25 Dec 22, Sunday

Random information on the term “Wine cocktail”:

Valencian Water (Valencian, Aigua de València.) is a cocktail made from a base of cava or champagne, orange juice, vodka and gin. In general, it is served in pitchers of various sizes and is consumed from a broad cocktail glass. It was made for the first time in 1959 by Constante Gil in the bar Café Madrid de Valencia in the city of Valencia, Spain.

According to the writer María Ángeles Arazo in her book Valencia Noche, the bar was frequented at that time by a group of Basque travellers that used to order “Agua de Bilbao” (Spanish, “Water of Bilbao”), referring to the bar’s best cava. Tired of always ordering the same thing, they challenged the owner to offer them something new and he suggested that they try the “Agua de Valencia”. They agreed to try what Gil made, and liking it, they continued to drink it in later visits.

For a decade the drink was known only to a small group of clients and it was not until the 1970s that it started to become known in the wider Valencian nightlife. Since then, it has grown to be a very popular drink.

Wine cocktail on Wikipedia

Random information on the term “KIR”:

Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, plants, and bacteria. They are activated by phosphatidylinositol 4,5-bisphosphate (PIP2). The malfunction of the channels has been implicated in several diseases. IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs). They may exist in the membrane as homo- or heterooligomers and each monomer possesses between 2 and 4 TMSs. In terms of function, these proteins transport potassium (K+), with a greater tendency for K+ uptake than K+ export. The process of inward-rectification was discovered by Denis Noble in cardiac muscle cells in 1960s and by Richard Adrian and Alan Hodgkin in 1970 in skeletal muscle cells.

A channel that is “inwardly-rectifying” is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell.

KIR on Wikipedia

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