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Possible Answers:
CAST.
Last seen on: –NewsDay Crossword January 20 2023
Thomas Joseph – King Feature Syndicate Crossword – Jan 9 2023
Random information on the term “Play group”:
A pre-school playgroup, or in everyday usage just a playgroup, is an organised group providing care and socialisation for children under five. The term is widely used in the United Kingdom. Playgroups are less formal than the preschool education of nursery schools. They do not provide full-time care, operating for only a few hours a day during school term time, often in the mornings only. They are staffed by nursery nurses or volunteers, not by nursery teachers, and are run by private individuals or charities, rather than by the state or companies.
In the United Kingdom, since around the 1980s, the traditional territory of the playgroup has been encroached on by the expansion of more formal nursery education, and playgroups often now cater only for two- and three-year-olds before they move onto a nursery school. Over the same period there has been an increase in the state supervision of playgroups.
In the United States, a playgroup is an organization of parents with the expressed intent to have the children come together and play. There are playgroups that cater to specific categories of parents, particularly including stay at home dads, stay at home moms, and working moms. In areas of the US where homeschooling is popular, it is not unusual to see groups specifically for homeschooling families. These can be part of localized or even national playgroups. Churches, rec centers, and other community organizations sometimes sponsor weekly or monthly playgroups. Age limits are determined by the individual group. Some groups have upper age limits and some do not. It is not unusual to see groups where, in addition to activities for the children, there are social events for the whole family or for parents only. In highly mobile communities, playgroups can be an important tool for building the social networks of young families who have recently relocated to the area. There are a number of resources online for parents to find playgroups in their area – including Playgroups USA and Social Toddler – both directories and social networks for parents in playgroups.
Random information on the term “CAST”:
The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized, controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality. It was conducted between 1986 and 1989 and included over 1700 patients in 27 centres. The study found that the tested drugs increased mortality instead of lowering it as was expected. The publication of these results in 1991/92, in combination with large follow-up studies for drugs that had not been tested in CAST, led to a paradigm shift in the treatment of MI patients. Class I and III antiarrhythmics are now only used with extreme caution after MI, or they are contraindicated completely. Heart Rhythm Society Distinguished Scientist D. George Wyse was a member of the CAST trial’s steering and executive committees.
The study was prompted by the fact that patients who suffer from myocardial infarctions (MIs) have a high risk of sudden death, presumably due to arrhythmia. Around the time of the study onset (1986), an estimated 8 to 15% of patients would die in the subsequent year following an MI, with about half of those deaths resulting from arrhythmia. This warranted the investigation as to whether PVC suppression could improve outcomes in post-MI patients. The trial was conducted by the National Heart, Lung, and Blood Institute.