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MME.
Last seen on: The New Yorker Tuesday, 25 April 2023 Crossword Answers
Random information on the term “MME”:
MME (2,4-dimethoxy-5-ethoxyamphetamine) is a lesser-known psychedelic drug. It is a dimethoxy-ethoxy analog of TMA-2. MME was first synthesized by Alexander Shulgin from ethylvanillin. In his book PiHKAL, the minimum dosage is listed as 40 mg and above, and the duration listed as 6–10 hours. Shulgin gives MME a ++ on the Shulgin Rating Scale.
Shulgin describes in his book an experiment with MME, in which he admistered varying amounts of the drug to mice via injections. Shulgin reports that 7 of the 9 mice injected with MME died as a result. After describing his experiment, Shulgin speculates that MME may have an LD50 value of around 60–80 mg/Kg in mice when injected. Shulgin describes that one of the mice began convulsing after being administered MME: “[…] the mouse went into a twitching series of convulsions (known as clonic in the trade) and in five minutes he was dead.” The convulsions Shulgin noted may have been a sympom of serotonin syndrome in the mouse due to MME’s affinity towards serotonin transporter in Mus musculus.