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Possible Answers:
LSD.
Last seen on: USA Today Crossword – Dec 21 2022
Random information on the term “Hallucinogenic drug”:
Psychedelic film
Serotonergic psychedelics (also known as serotonergic hallucinogens) are a subclass of hallucinogens with a method of action strongly tied to the neurotransmitter serotonin. Serotonin (often referred to as 5-HT, short for its full chemical name 5-hydroxytryptamine) is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions, many of which are not yet fully understood.
While the method of action of serotonergic psychedelics is not fully understood, serotonergic psychedelics are known to show affinities for various 5-HT receptors in different ways and levels, and may be classified by their activity at different 5-HT sub-types, particularly 5-HT1A, 5-HT2A, and 5-HT2C.
Many serotonergic psychedelics, such as the family of tryptamines, have very strong structural similarities to serotonin itself, which partially explains the affinity for certain 5-HT sites. It is almost unanimously agreed that serotonergic psychedelics produce their effect by acting as strong partial agonists at the 5-HT2A receptors. How this produces the psychedelic experience is unclear, but it is likely that it acts by increasing excitation in the cortex, possibly by specifically facilitating input from the thalamus, the major relay for sensory information input to the cortex. Additionally, researchers discovered that many serotonergic psychedelics are potent psychoplastogens, compounds capable of promoting rapid and sustained neural plasticity.
Hallucinogenic drug on Wikipedia
Random information on the term “LSD”:
Wystan Hugh Auden (/ˈwɪstən ˈhjuː ˈɔːdən/; 21 February 1907 – 29 September 1973) was a British-American poet. Auden’s poetry was noted for its stylistic and technical achievement, its engagement with politics, morals, love, and religion, and its variety in tone, form, and content. Some of his best known poems are about love, such as “Funeral Blues”; on political and social themes, such as “September 1, 1939” and “The Shield of Achilles”; on cultural and psychological themes, such as The Age of Anxiety; and on religious themes such as “For the Time Being” and “Horae Canonicae”.
He was born in York and grew up in and near Birmingham in a professional middle-class family. He attended various English independent (or public) schools and studied English at Christ Church, Oxford. After a few months in Berlin in 1928–29, he spent five years (1930–35) teaching in British private preparatory schools, then travelled to Iceland and China to write books about his journeys.