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Possible Answers:
RASP.
Last seen on: USA Today Crossword – Oct 8 2022
Random information on the term “Gravelly voice”:
A neoplasm (/ˈniː.oʊˌplæzəm, ˈniː.ə-/) is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor.
ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology.
Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek νέος- neo ‘new’ and πλάσμα plasma ‘formation, creation’.
Random information on the term “RASP”:
Reactive aldehyde species (RASP), also known as reactive aldehydes, refer to a class of electrophilic organic aldehyde molecules that are generally toxic or facilitate inflammation. RASP covalently react with amine groups (via Schiff base formation) and thiol groups (via Michael addition), particularly in proteins. Following threshold amounts of binding to the electrophile-responsive proteome, RASP modify protein function, as has been described with MAP kinase, protein kinase C, and other proteins that potentiate cytokine release and other aspects of inflammation. Binding of RASP to proteins can also lead to NF-kB activation, autoantibody formation, inflammasome activation, and activation of Scavenger Receptor A. RASP are formed via a variety of processes, including oxidation of alcohols, polyamine metabolism and lipid peroxidation. In addition to binding to proteins and other amine or thiol-containing molecules such as glutathione, RASP are metabolized by aldehyde dehydrogenases or aldehyde reductases. Due to the toxicity of RASP, only a small number of genetic mutations in aldehyde dehydrogenases allow for viable offspring, resulting in Sjögren-Larsson Syndrome, Succinic Semi-Aldehyde Dehydrogenase Deficiency, and other rare diseases.