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Possible Answers:
DRESS.
Last seen on: –Daily Boston Globe Crossword Tuesday, March 28, 2023
LA Times Crossword, Mon, Feb 6, 2023
Random information on the term “Frock”:
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A frock coat is a formal men’s coat characterised by a knee-length skirt cut all around the base just above the knee, popular during the Victorian and Edwardian periods (1830s–1910s). It is a fitted, long-sleeved coat with a centre vent at the back and some features unusual in post-Victorian dress. These include the reverse collar and lapels, where the outer edge of the lapel is often cut from a separate piece of cloth from the main body and also a high degree of waist suppression around the waistcoat, where the coat’s diameter round the waist is less than round the chest. This is achieved by a high horizontal waist seam with side bodies, which are extra panels of fabric above the waist used to pull in the naturally cylindrical drape. As was usual with all coats in the 19th century, shoulder padding was rare or minimal.
In the Age of Revolution around the end of the 18th century, men abandoned the justaucorps with tricorne hats for the directoire style: dress coat with breeches or increasingly pantaloons, and top hats. However, by the 1820s, the frock coat was introduced along with full-length trousers, perhaps inspired by the then casual country leisure wear frock. Early frock coats inherited the higher collars and voluminous lapels of the dress coat style at the time, and were sometimes offered in different, albeit increasingly dark, colours. Within its first next few years, though, plain black soon became the only established practice, and with a moderate collar. The top hat followed suit.
Random information on the term “DRESS”:
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Anticonvulsants (also known as antiepileptic drugs or antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder and borderline personality disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the excessive rapid firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain.
Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid (GABA) function. Several antiepileptic drugs have multiple or uncertain mechanisms of action. Next to the voltage-gated sodium channels and components of the GABA system, their targets include GABAA receptors, the GAT-1 GABA transporter, and GABA transaminase. Additional targets include voltage-gated calcium channels, SV2A, and α2δ. By blocking sodium or calcium channels, antiepileptic drugs reduce the release of excitatory glutamate, whose release is considered to be elevated in epilepsy, but also that of GABA. This is probably a side effect or even the actual mechanism of action for some antiepileptic drugs, since GABA can itself, directly or indirectly, act proconvulsively. Another potential target of antiepileptic drugs is the peroxisome proliferator-activated receptor alpha.