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Possible Answers:
DRESS.
Last seen on: Wall Street Journal Crossword – December 21 2022 – Choice Words
Random information on the term “Duds”:
Bomb disposal is an explosives engineering profession using the process by which hazardous explosive devices are rendered safe. Bomb disposal is an all-encompassing term to describe the separate, but interrelated functions in the military fields of explosive ordnance disposal (EOD) and improvised explosive device disposal (IEDD), and the public safety roles of public safety bomb disposal (PSBD) and the bomb squad.
The first professional civilian bomb squad was established by Sir Vivian Dering Majendie. As a Major in the Royal Artillery, Majendie investigated an explosion on 2 October 1874 in the Regent’s Canal, when the barge ‘Tilbury’, carrying six barrels of petroleum and five tons of gunpowder, blew up, killing the crew and destroying Macclesfield Bridge and cages at nearby London Zoo. In 1875, he framed The Explosives Act, the first modern legislation for explosives control. He also pioneered many bomb disposal techniques, including remote methods for the handling and dismantling of explosives. His advice during the Fenian dynamite campaign of 1881–85 was officially recognised as having contributed to the saving of lives. After Victoria Station was bombed on 26 February 1884 he defused a bomb built with a clockwork mechanism which might have gone off at any moment.
Random information on the term “DRESS”:
Anticonvulsants (also known as antiepileptic drugs or recently as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder and borderline personality disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the excessive rapid firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain.
Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid (GABA) function. Several antiepileptic drugs have multiple or uncertain mechanisms of action. Next to the voltage-gated sodium channels and components of the GABA system, their targets include GABAA receptors, the GAT-1 GABA transporter, and GABA transaminase. Additional targets include voltage-gated calcium channels, SV2A, and α2δ. By blocking sodium or calcium channels, antiepileptic drugs reduce the release of excitatory glutamate, whose release is considered to be elevated in epilepsy, but also that of GABA. This is probably a side effect or even the actual mechanism of action for some antiepileptic drugs, since GABA can itself, directly or indirectly, act proconvulsively. Another potential target of antiepileptic drugs is the peroxisome proliferator-activated receptor alpha.