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Possible Answers:
ALS.
Last seen on: Wall Street Journal Crossword – October 08 2022 – Exchanging Words
Random information on the term “ALS”:
1QBK, 2H4M, 2OT8, 2QMR, 2Z5J, 2Z5K, 2Z5M, 2Z5N, 2Z5O, 4FDD, 4FQ3, 4JLQ, 4OO6
3842
238799
ENSG00000083312
ENSMUSG00000009470
Q92973
Q8BFY9
NM_002270NM_153188
NM_001048267NM_178716
NP_001351224NP_001351225
NP_001041732NP_848831
Transportin-1 (or Importin-β 2) is a protein that in humans is encoded by the TNPO1 gene.
This protein is a karyopherin which interacts with nuclear localization sequence to target nuclear proteins to the nucleus. The classical karyopherin receptor complex, such as the complex that uses Importin-β1 (encoded by gene KPNB1), is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. However, Transportin-1 can directly bind to the cargo proteins and may not need importin alpha subunit to do it.
Transportin-1 is thought to use the same principal mechanism to carry out nuclear transport as other Importins. It mediates docking to the nuclear pore complex through binding to nucleoporin and is subsequently translocated through the pore by an energy requiring mechanism. Then, in the nucleus Ran binds to Transportin-1, it dissociates from cargo, and Transportin-1 is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Then Transportin-1 is free to bind new cargo.