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Possible Answers:
TSN.
Last seen on: Daily Crossword Club Crossword Wednesday, 19 April 2023
Random information on the term “TSN”:
1J1J, 3PJA, 3QB5, 4WYV
7247
22099
ENSG00000211460
ENSMUSG00000026374
Q15631
Q62348
NM_001261401NM_004622
NM_011650
NP_001248330NP_004613
NP_035780
Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.