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Possible Answers:
SACS.
Last seen on: –Daily Boston Globe Crossword Sunday, 24 September 2023
–USA Today Crossword – Apr 1 2023
L.A. Times Daily Crossword – Nov 3 2022
Random information on the term “SACS”:
1IUR, 3O10
26278
n/a
ENSG00000151835
n/a
Q9NZJ4
n/a
NM_001278055NM_014363NM_152752
n/a
NP_001264984NP_055178
n/a
Sacsin also known as DnaJ homolog subfamily C member 29 (DNAJC29) is a protein that in humans is encoded by the SACS gene. Sacsin is a Hsp70 co-chaperone.
This gene consists of nine exons including a gigantic exon spanning more than 12.8k bp. It encodes the sacsin protein, which includes a UBQ region at the N-terminus, a HEPN domain at the C-terminus and a DnaJ region upstream of the HEPN domain. This modular protein is essential for normal mitochondrial network organization. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy.