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MOTT.
Last seen on: Daily Crossword Club Crossword Monday, 27 November 2023
Random information on the term “MOTT”:
The Mycobacterium tuberculosis complex (MTC or MTBC) is a genetically related group of Mycobacterium species that can cause tuberculosis in humans or other animals.
It includes:
In addition, two branches exist which have phylogenetic similarities but are not completely described: the dassie and oryx bacilli. Oryx bacilli has been recently reclassified into a separate subspecies, orygis.
Members of the MTC can be distinguished from all other bacteria by the presence of 63 conserved signature indels (CSIs) present in diverse proteins that are exclusively shared by these pathogens. Due to their exclusivity for the MTC complex and presence in highly conserved regions of proteins, these CSIs provide novel means for functional and diagnostic studies (including potential targets for development of novel therapeutics).
Since 2018, all members of this species complex are considered synonyms of M. tuberculosis as far as bacterial nomenclature is concerned. The IJSEM article reports that M. africanum, M. bovis, M. caprae, M. pinnipedii are 99.21–99.92% identical to M. tuberculosis on the whole-genome level, failing the criteria to be considered independent species. The same applies to “M. canetti”, “M. mungi”, and “M. orygis”, species not validly published. The variation is even below the accepted level for subspecies. Authors of the article note that these names do refer to stable lineages with meaningful clinical distinctions, recommending that them become variants: M. bovis would become M. tuberculosis var. bovis, for example.